IFNγ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages

E. M. Bautista, T. W. Molitor

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

This study reports the effect of IFNγ on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFNγ profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFNγ on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFNγ may play an important role in protection.

Original languageEnglish (US)
Pages (from-to)1191-1200
Number of pages10
JournalArchives of Virology
Volume144
Issue number6
DOIs
StatePublished - Jul 22 1999

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