IGF system components as prognostic markers in breast cancer

Adrian V. Lee, Susan G. Hilsenbeck, Douglas Yee

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The insulin-like growth factor (IGF) family of ligands, receptors, and binding proteins can regulate breast cancer cell proliferation in vitro, and interruption of these pathways inhibits IGF-mediated cell proliferation. If the IGF family members are key regulators of breast cancer growth and progression in vivo, we would expect their expression to be an indicator of the prognosis of the disease. Thus, measurement of IGF expression may provide an indicator of the growth effect within a tumor, and provide new targets for treatment of the disease. In this review we will summarize the data generated thus far indicating that IGF family members are indicators of prognosis of breast cancer, and that measurement of the whole IGF family in concert may provide useful information for treatment strategies of breast cancer.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalBreast Cancer Research and Treatment
Volume47
Issue number3
DOIs
StatePublished - 1998

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

Keywords

  • Breast cancer
  • IGF
  • IGFBP
  • Prognosis
  • Treatment

Fingerprint Dive into the research topics of 'IGF system components as prognostic markers in breast cancer'. Together they form a unique fingerprint.

Cite this