Imaging cardiac extracellular matrices: A blueprint for regeneration

Jangwook P. Jung; Jayne M. Squirrell; Gary E. Lyons; Kevin W. Eliceiri; Brenda M. Ogle

doi:10.1016/j.tibtech.2011.12.001

Imaging cardiac extracellular matrices: A blueprint for regeneration

Jangwook P. Jung, Jayne M. Squirrell, Gary E. Lyons, Kevin W. Eliceiri, Brenda M. Ogle

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Once damaged, cardiac tissue does not readily repair and is therefore a primary target of regenerative therapies. One regenerative approach is the development of scaffolds that functionally mimic the cardiac extracellular matrix (ECM) to deliver stem cells or cardiac precursor populations to the heart. Technological advances in micro/nanotechnology, stem cell biology, biomaterials and tissue decellularization have propelled this promising approach forward. Surprisingly, technological advances in optical imaging methods have not been fully utilized in the field of cardiac regeneration. Here, we describe and provide examples to demonstrate how advanced imaging techniques could revolutionize how ECM-mimicking cardiac tissues are informed and evaluated.

Original language	English (US)
Pages (from-to)	233-240
Number of pages	8
Journal	Trends in biotechnology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.tibtech.2011.12.001
State	Published - Apr 2012
Externally published	Yes

Bibliographical note

Funding Information:
The authors would like to thank Jose A. Santiago for preparing cryo–SEM images and Leanne M. Olds for help with graphic illustrations. This research was supported by the National Institutes of Health (BMO, HL100014) and the American Heart Association (BMO, IRG5570039).

Keywords

Biomaterials
Developing heart
Extracellular matrix
Multimodality imaging
Tissue engineering

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title = "Imaging cardiac extracellular matrices: A blueprint for regeneration",

abstract = "Once damaged, cardiac tissue does not readily repair and is therefore a primary target of regenerative therapies. One regenerative approach is the development of scaffolds that functionally mimic the cardiac extracellular matrix (ECM) to deliver stem cells or cardiac precursor populations to the heart. Technological advances in micro/nanotechnology, stem cell biology, biomaterials and tissue decellularization have propelled this promising approach forward. Surprisingly, technological advances in optical imaging methods have not been fully utilized in the field of cardiac regeneration. Here, we describe and provide examples to demonstrate how advanced imaging techniques could revolutionize how ECM-mimicking cardiac tissues are informed and evaluated.",

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AU - Ogle, Brenda M.

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Imaging cardiac extracellular matrices: A blueprint for regeneration

Abstract

Bibliographical note

Keywords

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