Immune cell location and function during post-natal mammary gland development

Johanna R. Reed, Kathryn L. Schwertfeger

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Post-natal mammary gland development requires complex interactions between the epithelial cells and various cell types within the stroma. Recent studies have illustrated the importance of immune cells and their mediators during the various stages of mammary gland development. However, the mechanisms by which these immune cells functionally contribute to mammary gland development are only beginning to be understood. This review provides an overview of the localization of immune cells within the mammary gland during the various stages of post-natal mammary gland development. Furthermore, recent studies are summarized that illustrate the mechanisms by which these cells are recruited to the mammary gland and their functional roles in mammary gland development.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalJournal of mammary gland biology and neoplasia
Volume15
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • Eosinophil
  • Immune cell
  • Immune mediator
  • Macrophage
  • Mammary gland
  • Mast cell

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