Immune reconstitution after haploidentical donor and umbilical cord blood allogeneic hematopoietic cell transplantation

Hany Elmariah, Claudio G. Brunstein, Nelli Bejanyan

Research output: Contribution to journalReview articlepeer-review

Abstract

Allogeneic hematopoietic cell transplantation (HCT) is the only potentially curative therapy for a variety of hematologic diseases. However, this therapeutic platform is limited by an initial period when patients are profoundly immunocompromised. There is gradual immune recovery over time, that varies by transplant platform. Here, we review immune reconstitution after allogeneic HCT with a specific focus on two alternative donor platforms that have dramatically improved access to allogeneic HCT for patients who lack an HLA-matched related or unrelated donor: haploidentical and umbilical cord blood HCT. Despite challenges, interventions are available to mitigate the risks during the immunocompromised period including antimicrobial prophylaxis, modified immune suppression strategies, graft manipulation, and emerging adoptive cell therapies. Such interventions can improve the potential for long-term overall survival after allogeneic HCT.

Original languageEnglish (US)
Article number102
Pages (from-to)1-15
Number of pages15
JournalLife
Volume11
Issue number2
DOIs
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Allogeneic transplant
  • Haploidentical
  • Immune reconstitution
  • Umbilical cord blood

PubMed: MeSH publication types

  • Journal Article
  • Review

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