Immune-related conditions and acute leukemia in children with down syndrome: A children's oncology group report

Amy M. Linabery; Wenchao Li; Michelle A. Roesler; Logan G. Spector; Alan S. Gamis; Andrew F. Olshan; Nyla A. Heerema; Julie A. Ross

doi:10.1158/1055-9965.EPI-14-1181

Immune-related conditions and acute leukemia in children with down syndrome: A children's oncology group report

Amy M. Linabery, Wenchao Li, Michelle A. Roesler, Logan G. Spector, Alan S. Gamis, Andrew F. Olshan, Nyla A. Heerema, Julie A. Ross

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Abstract

Background: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.

Methods: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.

Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.

Conclusions and Impact: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

Original language	English (US)
Pages (from-to)	454-458
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	24
Issue number	2
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-1181
State	Published - Feb 1 2015

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© 2014 American Association for Cancer Research.

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abstract = "Background: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.Methods: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.Conclusions and Impact: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.",

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AU - Linabery, Amy M.

AU - Li, Wenchao

AU - Roesler, Michelle A.

AU - Spector, Logan G.

AU - Gamis, Alan S.

AU - Olshan, Andrew F.

AU - Heerema, Nyla A.

AU - Ross, Julie A.

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AB - Background: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.Methods: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.Conclusions and Impact: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

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Immune-related conditions and acute leukemia in children with down syndrome: A children's oncology group report

Abstract

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