TY - JOUR
T1 - Immunity through DNA deamination
AU - Neuberger, Michael S.
AU - Harris, Reuben S.
AU - Di Noia, Javier
AU - Petersen-Mahrt, Svend K.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.
AB - Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.
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U2 - 10.1016/S0968-0004(03)00111-7
DO - 10.1016/S0968-0004(03)00111-7
M3 - Review article
C2 - 12826402
AN - SCOPUS:0038713344
SN - 0968-0004
VL - 28
SP - 305
EP - 312
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 6
ER -
