Abstract
γ-Aminobutyric acid (GABA) is found in high concentrations in the pancreatic islet. In addition, enzymes regulating the level of GABA (L-glutamated decarboxylase and GABA-α-ketoglutarate transaminase) have been immunohistochemically localized in the medullary cells of the islet. In this study, an immunofluorescence and elution/restaining protocol is used to determine the distribution of GABA and either insulin, glucagon, or somatostatin in a tissue section. GABA was not detected within the iselt α- or δ-cells but was determined to be localized within the insulin-containing β-cells.
Original language | English (US) |
---|---|
Pages (from-to) | 1090-1095 |
Number of pages | 6 |
Journal | Diabetes |
Volume | 35 |
Issue number | 10 |
DOIs | |
State | Published - 1986 |