TY - JOUR
T1 - Immunology of type 1 diabetes
T2 - Intervention and prevention strategies
AU - Bertera, S.
AU - Alexander, A.
AU - Giannoukakis, N.
AU - Robbins, P. D.
AU - Trucco, M.
PY - 1999
Y1 - 1999
N2 - Type 1 diabetes is the outcome of a progressive and selective destruction of insulin-producing cells in the pancreatic islets of Langerhans. The precise cause and mechanism(s) that trigger the insulin- producing cell destruction are still unclear, although it is well accepted that an autoimmune process plays a central role in diabetes development among genetically susceptible children. Additionally, certain viral infections, especially those caused by Coxsackievirus B, have been associated with the onset of type 1 diabetes. Possible gene therapy-based prevention and intervention strategies are discussed, based on the most accepted models of type 1 diabetes pathogenesis.
AB - Type 1 diabetes is the outcome of a progressive and selective destruction of insulin-producing cells in the pancreatic islets of Langerhans. The precise cause and mechanism(s) that trigger the insulin- producing cell destruction are still unclear, although it is well accepted that an autoimmune process plays a central role in diabetes development among genetically susceptible children. Additionally, certain viral infections, especially those caused by Coxsackievirus B, have been associated with the onset of type 1 diabetes. Possible gene therapy-based prevention and intervention strategies are discussed, based on the most accepted models of type 1 diabetes pathogenesis.
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U2 - 10.1016/S0889-8529(05)70105-5
DO - 10.1016/S0889-8529(05)70105-5
M3 - Article
C2 - 10609123
AN - SCOPUS:0032804347
SN - 0889-8529
VL - 28
SP - 841
EP - 864
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -
