Abstract
The introduction of novel agents to the therapeutic armamentarium for oncologic, rheumatologic, and neurologic disorders has resulted in major clinical advances. These agents impact immune function, resulting in a discrete spectrum of infectious complications. Purine analogues and alemtuzumab alter cell-mediated immunity, resulting in opportunistic viral/fungal infections. Herpes zoster incidence increases with bortezomib. Hepatitis B reactivation may occur with rituximab. Cases of progressive multifocal leukoencephalopathy have occurred following monoclonal antibody therapy. Tumor necrosis factor-α inhibitor therapy is complicated by tuberculosis reactivation and fungal infections. We summarize the impact of these therapies on pathogenesis and spectrum of infection complicating their usage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S360-S364 |
| Journal | Clinical Infectious Diseases |
| Volume | 59 |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
Bibliographical note
Funding Information:Supplement sponsorship. This article appeared as part of the supplement “The Third Infections in Cancer Symposium,” sponsored by the National Institute of Health, Agency for Healthcare Research and Quality.
Keywords
- Alemtuzumab
- Bortezomib
- Fludarabine
- Hepatitis B
- Tumor necrosis factor-α inhibitors
