Abstract
One-year graft survival rates of 80-90% can now be achieved routinely for primary cadaveric transplants with a variety of CSA-containing regimens. Further improvement of these excellent results may be difficult, since large numbers of patients must be evaluated to provide meaningful conclusions. On the other hand, long-term follow-up of CSA-treated patients has revealed a trend of undaunted allograft attrition with time, with concerns regarding the potential development of neoplasms and progressive nephrotoxicity. Therefore, future efforts should be directed at improving long-term allograft results at 5 to 10 yr, and may be sought through better use of currently available immunosuppressants or from newer agents.
Original language | English (US) |
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Pages (from-to) | 65-85 |
Number of pages | 21 |
Journal | Clinical Transplantation |
Volume | 5 |
Issue number | 2 I |
State | Published - Jan 1 1991 |
Keywords
- azathioprine
- cyclosporine
- immunosuppression
- renal transplantation