Impact of antiretroviral drugs on the microbiome: Unknown answers to important questions

Sandra Pinto-Cardoso, Nichole R. Klatt, Gustavo Reyes-Terán

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Purpose of review Little is known on how different antiretroviral (ARV) drugs affect the gut microbiome in HIV infection; and conflicting data exists on the effect of ARV drugs on residual inflammation/immune activation and microbial translocation. Recent findings Gut microbiome involvement in the transmission and pathogenesis of HIV infection is increasingly being recognized. Various studies have shown that antiretroviral therapy (ART) is unable to restore gut health despite effective suppression of plasma HIV viremia. Indeed, the resolution of residual inflammation and gut microbial translocation is partial under ART. Very recent studies have provided new evidence that ARV combinations can differentially affect the gut microbiome, immune activation and microbial translocation. Furthermore, a recent article uncovered a link between drug metabolism and specific microbial species indicating that microbes can directly metabolically degrade ARV drugs when administered topically. Summary There are still many unanswered questions regarding ARVs and the gut microbiome. It is, therefore, critical for researchers to address the effect of distinct ARV drugs on the microbiome and vice versa: The effects of the microbiome on ARV drug metabolism, and speculate about possible therapeutic avenues.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalCurrent Opinion in HIV and AIDS
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Bibliographical note

Funding Information:
S.P.C. and G.R.T. are supported by grants by the Mexican Government (Comisión de Equidad y Género de las Legislaturas LX-LXI and Comisión de Igualdad de Gén-ero de la Legislatura LXII de la H. Cámara de Diputados de la República Mexicana). N.R.K.’s microbiome studies are supported by NIH grants: NIDDK RO1DK112254, NIH/NIDA DP13A037979 and NIH/NIAID R01AI128782.

Funding Information:
NIH grants: NIDDK RO1DK112254, NIH/NIDA DP13A037979 and NIH/NIAID R01AI128782.

Publisher Copyright:
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

Keywords

  • antimicrobial properties
  • antiretroviral drugs
  • butyrate-producing bacteria
  • gut microbiome
  • microbial dysbiosis

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