Improved long-term survival of dialysis patients after near-total parathyroidectomy

Jyotirmay Sharma, Paolo Raggi, Nancy Kutner, James Bailey, Rebecca Zhang, Yijian Huang, Charles A. Herzog, Collin Weber

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Background: Severe secondary hyperparathyroidism, which is associated with life-threatening complications, can develop in dialysis-dependent end-stage renal disease patients. The aim of this study was to compare short- and long-term mortality in dialysis patients who underwent near-total parathyroidectomy (NTPTX) and matched nonoperated controls. Study Design: We identified 150 dialysis patients who underwent NTPTX (1993-2009) at our institution and compared them with 1,044 nonoperated control patients identified in the US Renal Data System registry, matched for age, sex, race, diabetes as cause of kidney failure, years on dialysis, and dialysis modality. Survival outcomes were estimated using multivariable Cox proportional hazards models with stratification on the matching sets, adjusted for cardiovascular comorbidities, smoking, inability to ambulate/transfer, and payor status. Results: During a follow-up of a mean of 3.6 years (range 0.1 month to 16.4 years), NTPTX patients had a significant reduction in the long-term risk of all-cause death (hazard ratio = 0.68; 95% CI, 0.52-0.89; p = 0.006) compared with controls. Thirty-day mortality rates for NTPTX patients and controls were 246 vs 105 per 1,000 person-years (p = 0.21). In adjusted analyses, NTPTX patients had a 37% reduced risk of all-cause death and a 33% reduced risk of cardiovascular death compared with controls. A durable reduction in mean parathyroid hormone was observed after NTPTX; from 1,776 ± 1,416.6 pg/mL to 301 ± 285.7 pg/mL (p < 0.0001). Conclusions: In our center, NTPTX in dialysis patients was associated with a significant reduction in long-term risk of death compared with matched control patients, without a significantly increased short-term risk.

Original languageEnglish (US)
Pages (from-to)400-407
Number of pages8
JournalJournal of the American College of Surgeons
Volume214
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • CKD
  • NTPTX
  • PTH
  • PTX
  • SAF
  • Standard Analysis File
  • US Renal Data System
  • USRDS
  • chronic kidney disease
  • near-total parathyroidectomy
  • parathyroid hormone
  • parathyroidectomy
  • sHPT
  • secondary hyperparathyroidism

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