Improved Simultaneous Multi-Slice Imaging for Perfusion Cardiac MRI Using Outer Volume Suppression and Regularized Reconstruction

Omer Burak Demirel, Sebastian Weingartner, Steen Moeller, Mehmet Akcakaya

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Perfusion cardiac MRI (CMR) is a radiation-free and noninvasive imaging tool which has gained increasing interest for the diagnosis of coronary artery disease. However, resolution and coverage are limited in perfusion CMR due to the necessity of single snap-shot imaging during the first-pass of a contrast agent. Simultaneous multi-slice (SMS) imaging has the potential for high acceleration rates with minimal signal-to-noise ratio (SNR) loss. However, its utility in CMR has been limited to moderate acceleration factors due to residual leakage artifacts from the extra-cardiac tissue such as the chest and the back. Outer volume suppression (OVS) with leakage-blocking reconstruction has been used to enable higher acceleration rates in perfusion CMR, but suffers from higher noise amplification. In this study, we sought to augment OVS-SMS/MB imaging with a regularized leakage-blocking reconstruction algorithm to improve image quality. Results from highly-accelerated perfusion CMR show that the method improves upon SMS-SPIRiT in terms of leakage reduction and split slice (ss)-GRAPPA in terms of noise mitigation.

Original languageEnglish (US)
Title of host publicationISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages1954-1957
Number of pages4
ISBN (Electronic)9781538693308
DOIs
StatePublished - Apr 2020
Event17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 - Iowa City, United States
Duration: Apr 3 2020Apr 7 2020

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2020-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference17th IEEE International Symposium on Biomedical Imaging, ISBI 2020
CountryUnited States
CityIowa City
Period4/3/204/7/20

Bibliographical note

Funding Information:
This work was partially supported by NIH R00HL111410, NIH P41EB027061 and NSF CAREER CCF-1651825. Ö.B. Demirel was partially supported by an AHA Predoctoral Fellowship.

Publisher Copyright:
© 2020 IEEE.

Keywords

  • Magnetic resonance imaging
  • accelerated MRI
  • myocardial perfusion
  • outer volume suppression
  • parallel imaging
  • simultaneous multi-slice imaging

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