Improved subtraction by adiabatic FAIR perfusion imaging

For pulsed arterial spin labeling techniques (e.g., FAIR), mismatches between the imaging and inversion slice profile result in a nonperfusion-related offset. Several methods have been proposed to reduce subtraction errors in FAIR imaging. Here an acquisition method for FAIR experiments based on adiabatic principles is proposed. It is shown that with adiabatic pulses the same pulse can be used for labeling and echo refocusing, thereby reducing the mismatch between imaging and labeling slice. A twofold reduction in subtraction errors compared to 5-lobe sinc excitation was shown both experimentally and by simulation. Magn Reson Med 47:2002.