Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition

Cosima Hirschberg; Nikolaj Sølvkær Jensen; Johan Boetker; Anders Østergaard Madsen; Tommi O. Kaäriaïnen; Marja Leena Kaäriaïnen; Pekka Hoppu; Steven M. George; Matti Murtomaa; Changquan Calvin Sun; Jens Risbo; Jukka Rantanen

doi:10.1021/acs.oprd.9b00247

Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition

Cosima Hirschberg, Nikolaj Sølvkær Jensen, Johan Boetker, Anders Østergaard Madsen, Tommi O. Kaäriaïnen, Marja Leena Kaäriaïnen, Pekka Hoppu, Steven M. George, Matti Murtomaa, Changquan Calvin Sun, Jens Risbo, Jukka Rantanen

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The particulate properties of a material after primary manufacturing have a large impact on the secondary manufacturing processes. Especially, powder characteristics leading to poor flowability are critical and need to be controlled at the late steps of primary operations. The surface properties of the primary particles are hereby one of the determining factors for the behavior of particulate systems. Materials with different particulate properties were coated using atomic layer deposition (ALD) to apply an ultrathin film of TiO₂ on the primary particles. The presence of TiO₂ coating was confirmed using X-ray photoelectron spectroscopy. Five TiO₂ ALD layers on the particle surface were enough to quadruple the flowability of a partially crystalline material and to triple the flowability of an amorphous material. The coating process did not change the solid form of the materials and did not affect other critical characteristics related to the functionality of the materials. Altogether, the ALD coating of powders provides new possibilities as a scalable and potentially continuously operating process that can solve problems related to powder flowability during handling of bulk powders.

Original language	English (US)
Pages (from-to)	2362-2368
Number of pages	7
Journal	Organic Process Research and Development
Volume	23
Issue number	11
DOIs	https://doi.org/10.1021/acs.oprd.9b00247
State	Published - Nov 15 2019

Bibliographical note

Funding Information:
This study was funded by Innovation Fund Denmark; Project: High Quality Dry Products with Superior Functionality and Stability—Q-Dry; file no: 5150-00024B. Funding from NordForsk for the Nordic University Hub project for mobility during the project is acknowledged #85352 (Nordic POP, Patient Oriented Products). The XPS measurements were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundations through the Material Research Science and Engineering Center program. We thank Kunlin Wang for her help with the XPS measurements.

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

atomic layer deposition (ALD)
materials science
particle coating
powder properties
surface chemistry

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Hirschberg, C., Jensen, N. S., Boetker, J., Madsen, A. Ø., Kaäriaïnen, T. O., Kaäriaïnen, M. L., Hoppu, P., George, S. M., Murtomaa, M., Sun, C. C., Risbo, J., & Rantanen, J. (2019). Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition. Organic Process Research and Development, 23(11), 2362-2368. https://doi.org/10.1021/acs.oprd.9b00247

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abstract = "The particulate properties of a material after primary manufacturing have a large impact on the secondary manufacturing processes. Especially, powder characteristics leading to poor flowability are critical and need to be controlled at the late steps of primary operations. The surface properties of the primary particles are hereby one of the determining factors for the behavior of particulate systems. Materials with different particulate properties were coated using atomic layer deposition (ALD) to apply an ultrathin film of TiO2 on the primary particles. The presence of TiO2 coating was confirmed using X-ray photoelectron spectroscopy. Five TiO2 ALD layers on the particle surface were enough to quadruple the flowability of a partially crystalline material and to triple the flowability of an amorphous material. The coating process did not change the solid form of the materials and did not affect other critical characteristics related to the functionality of the materials. Altogether, the ALD coating of powders provides new possibilities as a scalable and potentially continuously operating process that can solve problems related to powder flowability during handling of bulk powders.",

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note = "Funding Information: This study was funded by Innovation Fund Denmark; Project: High Quality Dry Products with Superior Functionality and Stability—Q-Dry; file no: 5150-00024B. Funding from NordForsk for the Nordic University Hub project for mobility during the project is acknowledged #85352 (Nordic POP, Patient Oriented Products). The XPS measurements were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundations through the Material Research Science and Engineering Center program. We thank Kunlin Wang for her help with the XPS measurements. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

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N2 - The particulate properties of a material after primary manufacturing have a large impact on the secondary manufacturing processes. Especially, powder characteristics leading to poor flowability are critical and need to be controlled at the late steps of primary operations. The surface properties of the primary particles are hereby one of the determining factors for the behavior of particulate systems. Materials with different particulate properties were coated using atomic layer deposition (ALD) to apply an ultrathin film of TiO2 on the primary particles. The presence of TiO2 coating was confirmed using X-ray photoelectron spectroscopy. Five TiO2 ALD layers on the particle surface were enough to quadruple the flowability of a partially crystalline material and to triple the flowability of an amorphous material. The coating process did not change the solid form of the materials and did not affect other critical characteristics related to the functionality of the materials. Altogether, the ALD coating of powders provides new possibilities as a scalable and potentially continuously operating process that can solve problems related to powder flowability during handling of bulk powders.

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Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition

Abstract

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Keywords

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