TY - JOUR
T1 - In vitro activity of sorghum-selective fluorophenyl urea herbicides
AU - Gardner, Gary
AU - Pilgram, K. H.
AU - Brown, Lloyd J.
AU - Bozarth, G. A.
PY - 1985/12
Y1 - 1985/12
N2 - The use of N-cyclopropyl-N′-(2-fluorophenyl) urea as a selective herbicide in grain sorghum has recently been disclosed (U.S.P. 4,344,916). Evaluation of analogs of this compound has included two assays on isolated pea chloroplasts-photosynthetic electron transport and competition for atrazine binding sites. Of all the analogs studied in at least one of these assays, the most active in vitro were the N-cyclopropyl-, N-n-butyl-, and N-n-pentyl-derivatives of 2,5-difluorophenyl urea. The two in vitro assays correlated well with each other, and binding activity demonstrated a strong correlation with whole-plant phytotoxicity following postemergence application. Several postulated sorghum metabolites of N-cyclopropyl-N′-(2-fluorophenyl) urea showed weak or no activity in vitro, as would be expected from the compoud's selectivity properties.
AB - The use of N-cyclopropyl-N′-(2-fluorophenyl) urea as a selective herbicide in grain sorghum has recently been disclosed (U.S.P. 4,344,916). Evaluation of analogs of this compound has included two assays on isolated pea chloroplasts-photosynthetic electron transport and competition for atrazine binding sites. Of all the analogs studied in at least one of these assays, the most active in vitro were the N-cyclopropyl-, N-n-butyl-, and N-n-pentyl-derivatives of 2,5-difluorophenyl urea. The two in vitro assays correlated well with each other, and binding activity demonstrated a strong correlation with whole-plant phytotoxicity following postemergence application. Several postulated sorghum metabolites of N-cyclopropyl-N′-(2-fluorophenyl) urea showed weak or no activity in vitro, as would be expected from the compoud's selectivity properties.
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U2 - 10.1016/0048-3575(85)90139-7
DO - 10.1016/0048-3575(85)90139-7
M3 - Article
AN - SCOPUS:0022297947
SN - 0048-3575
VL - 24
SP - 285
EP - 297
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
IS - 3
ER -