Abstract
Cancerous tissues have electrical-conductivity signatures different from normal tissues, which contain potentially useful information for early detection. Despite recent advancements in electrical-conductivity imaging and its applications, imaging electrical conductivities with high spatial resolution remains a challenge for non-invasive diagnosis of early-stage cancer. Among the various electrical-conductivity imaging methods, magnetoacoustic tomography with magnetic induction (MAT-MI) is a promising technology for non-invasive detection of breast cancer. However, previous efforts to use MAT-MI for cancer imaging have suffered due to insufficient spatial resolution. In this work, we have developed a high-frequency MAT-MI (hfMAT-MI) system with a 2-D spatial resolution of 1 mm, a significant improvement over previous methods. Furthermore, we demonstrated the performance of this method using an in vivo cancer model in nude mice with human breast xenograft hindlimb tumors. hfMAT-MI was able to resolve not only the boundaries between cancerous and healthy tissues, but also the tumors' internal structures. Importantly, we were able to track a growing tumor using our hfMAT-MI method for the first time in an in vivo mouse model, demonstrating the promise of this magneto-acoustic imaging system for effective detection and diagnosis of early-stage breast cancer.
Original language | English (US) |
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Article number | 7462269 |
Pages (from-to) | 2301-2311 |
Number of pages | 11 |
Journal | IEEE Transactions on Medical Imaging |
Volume | 35 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2016 |
Bibliographical note
Funding Information:This work was supported in part by the National Institutes of Health under Grant EB014353, EB017069, and U01 HL117664 and in part by The National Science Foundation under Grant CBET-1450956, and CBET-1264782.
Publisher Copyright:
© 2016 IEEE.
Keywords
- Bioimpedance
- MAT-MI
- cancer detection
- electrical conductivity imaging
- electrical impedance imaging
- magnetoacoustic tomography with magnetic induction