In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans

Ameer Khowaja, In Young Choi, Elizabeth R. Seaquist, Gülin Öz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Glycogen serves as an important energy reservoir in the human body. Despite the abundance of glycogen in the liver and skeletal muscles, its concentration in the brain is relatively low, hence its significance has been questioned. A major challenge in studying brain glycogen metabolism has been the lack of availability of non-invasive techniques for quantification of brain glycogen in vivo. Invasive methods for brain glycogen quantification such as post mortem extraction following high energy microwave irradiation are not applicable in the human brain. With the advent of 13C Magnetic Resonance Spectroscopy (MRS), it has been possible to measure brain glycogen concentrations and turnover in physiological conditions, as well as under the influence of stressors such as hypoglycemia and visual stimulation. This review presents an overview of the principles of the 13C MRS methodology and its applications in both animals and humans to further our understanding of glycogen metabolism under normal physiological and pathophysiological conditions such as hypoglycemia unawareness.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalMetabolic Brain Disease
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

Keywords

  • Brain glycogen
  • Hypoglycemia
  • Magnetic Resonance Spectroscopy (MRS)
  • Metabolism
  • Stress response

Fingerprint

Dive into the research topics of 'In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans'. Together they form a unique fingerprint.

Cite this