In vivo 1H NMR spectroscopy of the human brain at 7 T

Ivan Tká, Peter Andersen, Gregor Adriany, Hellmut Merkle, Kâmil Uurbil, Rolf Gruetter

Research output: Contribution to journalArticlepeer-review

284 Scopus citations

Abstract

In vivo 1H NMR spectra from the human brain were measured at 7 T. Ultrashort echo-time STEAM was used to minimize J-modulation and signal attenuation caused by the shorter T2 of metabolites. Precise adjustment of higher-order shims, which was achieved with FASTMAP, was crucial to benefit from this high magnetic field. Sensitivity improvements were evident from single-shot spectra and from the direct detection of glucose at 5.23 ppm in 8-ml volumes. The linewidth of the creatine methyl resonance was at best 9 Hz. In spite of the increased linewidth of singlet resonances at 7 T, the ability to resolve overlapping multiplets of J-coupled spin systems, such as glutamine and glutamate, was substantially increased. Characteristic spectral patterns of metabolites, e.g., myo-inositol and taurine, were discernible in the in vivo spectra, which facilitated an unambiguous signal assignment.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalMagnetic resonance in medicine
Volume46
Issue number3
DOIs
StatePublished - 2001

Keywords

  • H NMR spectroscopy
  • High magnetic field
  • Human brain
  • Resolutio

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