TY - JOUR
T1 - Incidence and lifetime risk of motor neuron disease in the United Kingdom
T2 - A population-based study
AU - Alonso, A.
AU - Logroscino, G.
AU - Jick, S. S.
AU - Hernán, M. A.
PY - 2009/6
Y1 - 2009/6
N2 - Background and purpose: To estimate the incidence and lifetime risk of motor neuron disease (MND) in a population-based sample in the United Kingdom. Methods: We identified new cases of MND during the period 1990-2005 in the General Practice Research Database, which includes clinical information from more than 3 million Britons enrolled with selected general practitioners. Individuals with a first medical diagnosis of MND recorded in the database were considered incident cases of the disease. The positive predictive value of the computer-based diagnosis was estimated through review of a sample of medical records from potential MND cases. Results: In the period 1990-2005, 830 new cases of MND were identified. Age-standardized incidence of MND was 2.6 per 100 000 persons per year in women (95% CI: 2.3, 2.8) and 3.9 in men (95% CI: 3.6, 4.3). Incidence for both sexes peaked between 75 and 79 years. The rate of MND in men was 54% higher than in women (95% CI: 33%, 77%). The lifetime risk of MND, adjusting for competing causes of death, was 1 in 472 (2.1 per 1000) in women and 1 in 350 (2.9 per 1000) in men. No increase in MND incidence over time was apparent. Conclusion: In this population-based database, we found that MND incidence is higher in men than women, peaking in both sexes between 75 and 79 years.
AB - Background and purpose: To estimate the incidence and lifetime risk of motor neuron disease (MND) in a population-based sample in the United Kingdom. Methods: We identified new cases of MND during the period 1990-2005 in the General Practice Research Database, which includes clinical information from more than 3 million Britons enrolled with selected general practitioners. Individuals with a first medical diagnosis of MND recorded in the database were considered incident cases of the disease. The positive predictive value of the computer-based diagnosis was estimated through review of a sample of medical records from potential MND cases. Results: In the period 1990-2005, 830 new cases of MND were identified. Age-standardized incidence of MND was 2.6 per 100 000 persons per year in women (95% CI: 2.3, 2.8) and 3.9 in men (95% CI: 3.6, 4.3). Incidence for both sexes peaked between 75 and 79 years. The rate of MND in men was 54% higher than in women (95% CI: 33%, 77%). The lifetime risk of MND, adjusting for competing causes of death, was 1 in 472 (2.1 per 1000) in women and 1 in 350 (2.9 per 1000) in men. No increase in MND incidence over time was apparent. Conclusion: In this population-based database, we found that MND incidence is higher in men than women, peaking in both sexes between 75 and 79 years.
KW - Incidence
KW - Lifetime risk
KW - Motor neuron disease
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U2 - 10.1111/j.1468-1331.2009.02586.x
DO - 10.1111/j.1468-1331.2009.02586.x
M3 - Article
C2 - 19475756
AN - SCOPUS:65449123115
SN - 1351-5101
VL - 16
SP - 745
EP - 751
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 6
ER -