Increased Ascitic Fluid Prorenin in the Ovarian Hyperstimulation Syndrome

Mark E. Rosenberg, John K. Mckenzie, Irene M. Mckenzie, Asad Junaid, George E. Tagatz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Three patients developed severe ovarian hyperstimulation syndrome (OHS) as a complication of ovarian hyperstimulation for in vitro fertilization. These patients presented with ovarian enlargement, vascular volume depletion, pleural effusions, and exudative ascites. A unique feature of the ascites in OHS was the markedly elevated renin concentration, the majority of which was prorenin. We speculate the renin-angiotensin system (RAS) may play a pathophysiologic role in the localized capillary leak that develops in OHS.

Original languageEnglish (US)
Pages (from-to)427-429
Number of pages3
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - 1994


  • Ovarian hyperstimulation syndrome
  • angiotensin
  • ascites
  • prorenin


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