Indirect cell death and the LQ model in SBRT and SRS

Chang W. Song, Stephanie Terezakis, Bahman Emami, Robert J. Griffin, Paul W. Sperduto, Mi Sook Kim, L. Chinsoo Cho

Research output: Contribution to journalReview articlepeer-review

Abstract

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of Radiosurgery and SBRT
Volume7
Issue number1
StatePublished - 2020

Bibliographical note

Funding Information:
This work was supported by the Wurtele Funds and the Karen Wyckoff Rain in Sarcoma Foundation in the Masonic Cancer Center at the University of Minnesota.

Keywords

  • Indirect cell death
  • LQ model
  • SBRT
  • Secondary cell death
  • SRS

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