Indirect cell death and the LQ model in SBRT and SRS

Chang W. Song; Stephanie Terezakis; Bahman Emami; Robert J. Griffin; Paul W. Sperduto; Mi Sook Kim; L. Chinsoo Cho

Indirect cell death and the LQ model in SBRT and SRS

Chang W. Song, Stephanie Terezakis, Bahman Emami, Robert J. Griffin, Paul W. Sperduto, Mi Sook Kim, L. Chinsoo Cho

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Journal of Radiosurgery and SBRT
Volume	7
Issue number	1
State	Published - 2020

Bibliographical note

Funding Information:
This work was supported by the Wurtele Funds and the Karen Wyckoff Rain in Sarcoma Foundation in the Masonic Cancer Center at the University of Minnesota.

Keywords

Indirect cell death
LQ model
SBRT
Secondary cell death
SRS

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title = "Indirect cell death and the LQ model in SBRT and SRS",

abstract = "High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS. ",

keywords = "Indirect cell death, LQ model, SBRT, Secondary cell death, SRS",

author = "Song, {Chang W.} and Stephanie Terezakis and Bahman Emami and Griffin, {Robert J.} and Sperduto, {Paul W.} and Kim, {Mi Sook} and Cho, {L. Chinsoo}",

note = "Funding Information: This work was supported by the Wurtele Funds and the Karen Wyckoff Rain in Sarcoma Foundation in the Masonic Cancer Center at the University of Minnesota.",

year = "2020",

language = "English (US)",

volume = "7",

pages = "1--4",

journal = "Journal of Radiosurgery and SBRT",

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T1 - Indirect cell death and the LQ model in SBRT and SRS

AU - Song, Chang W.

AU - Terezakis, Stephanie

AU - Emami, Bahman

AU - Griffin, Robert J.

AU - Sperduto, Paul W.

AU - Kim, Mi Sook

AU - Cho, L. Chinsoo

N1 - Funding Information: This work was supported by the Wurtele Funds and the Karen Wyckoff Rain in Sarcoma Foundation in the Masonic Cancer Center at the University of Minnesota.

PY - 2020

Y1 - 2020

N2 - High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

AB - High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

KW - Indirect cell death

KW - LQ model

KW - SBRT

KW - Secondary cell death

KW - SRS

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JO - Journal of Radiosurgery and SBRT

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