High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Radiosurgery and SBRT|
|State||Published - 2020|
Bibliographical noteFunding Information:
This work was supported by the Wurtele Funds and the Karen Wyckoff Rain in Sarcoma Foundation in the Masonic Cancer Center at the University of Minnesota.
- Indirect cell death
- LQ model
- Secondary cell death