Indomethacin alters the effects of substance-P and VIP on isolated airway smooth muscle

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Abstract

Both substance-P and vasoactive intestinal peptide (VIP) have previously been demonstrated to contract and relax, respectively, the isolated guinea pig trachea. In addition, substance-P and VIP have been localized within the pulmonary innervation of various species. In the present studies, substance-P was found to cause a concentration-related contraction of isolated lung parenchymal strips of the guinea pig, as well as isolated tracheal strips. VIP caused a significant concentration-related relaxation of the isolated tracheal strip, but not the lung parenchymal strip. Indomethacin, a prostaglandin synthetase inhibitor, potentiated the contractile response of the trachea to substance-P and inhibited the VIP- and isoproterenol-induced relaxation. These studies are potentially important in understanding the pathogenesis of bronchospastic disorders, since alterations in prostaglandin biosynthesis may result in hyperreactivity of airways to contractile agonists such as neurotransmitters, as well as an inhibition of relaxation induced by endogenous substances such as VIP or β agonists.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalPeptides
Volume4
Issue number4
DOIs
StatePublished - 1983

Bibliographical note

Funding Information:
This work was supported by N|H grant HL28443. The excellent technical assistance of Ms. Barbara Elmquist is ggatefully acknowledged.

Keywords

  • Lung parenchyma
  • Prostaglandins
  • Substance-P
  • Trachea
  • Vasoactive intestinal peptide

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