Induction of mutagenesis and transformation by the extract of alernaria alternata isolated from grains in linxian, China

Zigang Dong, Guiting Liu, Ziming Dong, Yuzhen Qian, Yuhui An, Jian Miao, Yingzhong Zhen

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41 Scopus citations

Abstract

Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.

Original languageEnglish (US)
Pages (from-to)989-991
Number of pages3
JournalCarcinogenesis
Volume8
Issue number7
DOIs
StatePublished - Jul 1 1987

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