TY - JOUR
T1 - Infant leukemia and congenital abnormalities
T2 - A Children's Oncology Group study
AU - Johnson, Kimberly J.
AU - Roesler, Michelle A.
AU - Linabery, Amy M.
AU - Hilden, Joanne M.
AU - Davies, Stella M.
AU - Ross, Julie A.
PY - 2010/7/15
Y1 - 2010/7/15
N2 - Background. Leukemia in infants is rare and has not been well studied apart from leukemia in older children. Differences in survival and the molecular characteristics of leukemia in infants versus older children suggest a distinct etiology, likely involving prenatal factors. Procedure. We examined the association between eight categories of maternally reported congenital abnormalities (CAs) (cleft lip or palate, spina bifida or other spinal defect, large or multiple birthmarks, other chromosomal abnormalities, small head or microcephaly, rib abnormalities, urogenital abnormalities, and other) and infant leukemia in a case-control study. The study included 443 cases diagnosed at <1 year of age at a Children's Oncology Group Institution in the United States or Canada from 1996 to 2006 and 324 controls. Controls were recruited from the cases' geographic area either by random digit dialing (1999-2002) or through birth certificates (2003-2008) and were frequency-matched to cases on birth year. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression after adjustment for birth year and a measure of follow-up time to account for differences in the CA observation period. Results. No statistically significant associations were observed between infant leukemia and any CA (OR=1.2; 95% CI: 0.8-1.9), birthmarks (OR=1.4; 95% CI: 0.7-2.5), urogenital abnormalities (OR=0.7; 95% CI: 0.2-2.0), or other CA (OR=1.4; 95% CI: 0.7-2.8). Results were similar for acute lymphoblastic and myeloid leukemia cases. Fewer than five subjects were in the remaining CA categories precluding analysis. Conclusions. Overall, we did not find evidence to support an association between CAs and infant leukemia.
AB - Background. Leukemia in infants is rare and has not been well studied apart from leukemia in older children. Differences in survival and the molecular characteristics of leukemia in infants versus older children suggest a distinct etiology, likely involving prenatal factors. Procedure. We examined the association between eight categories of maternally reported congenital abnormalities (CAs) (cleft lip or palate, spina bifida or other spinal defect, large or multiple birthmarks, other chromosomal abnormalities, small head or microcephaly, rib abnormalities, urogenital abnormalities, and other) and infant leukemia in a case-control study. The study included 443 cases diagnosed at <1 year of age at a Children's Oncology Group Institution in the United States or Canada from 1996 to 2006 and 324 controls. Controls were recruited from the cases' geographic area either by random digit dialing (1999-2002) or through birth certificates (2003-2008) and were frequency-matched to cases on birth year. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression after adjustment for birth year and a measure of follow-up time to account for differences in the CA observation period. Results. No statistically significant associations were observed between infant leukemia and any CA (OR=1.2; 95% CI: 0.8-1.9), birthmarks (OR=1.4; 95% CI: 0.7-2.5), urogenital abnormalities (OR=0.7; 95% CI: 0.2-2.0), or other CA (OR=1.4; 95% CI: 0.7-2.8). Results were similar for acute lymphoblastic and myeloid leukemia cases. Fewer than five subjects were in the remaining CA categories precluding analysis. Conclusions. Overall, we did not find evidence to support an association between CAs and infant leukemia.
KW - Birth defects
KW - Congenital abnormalities
KW - Infant leukemia
KW - Risk factors
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U2 - 10.1002/pbc.22495
DO - 10.1002/pbc.22495
M3 - Article
C2 - 20486175
AN - SCOPUS:77953283257
SN - 1545-5009
VL - 55
SP - 95
EP - 99
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 1
ER -