Inflammation associates with impaired small arterial elasticity early in HIV disease

INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

doi:10.1093/ofid/ofy117

Inflammation associates with impaired small arterial elasticity early in HIV disease

INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	6
DOIs	https://doi.org/10.1093/ofid/ofy117
State	Published - Jun 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by the National Institute of Allergy and Infectious Diseases (grant numbers UM1-AI068641, UM1-AI120197; United States); Agence Nationale de Recherches sur le SIDA et les Hipatites Virales (France); National Health and Medical Research Council (Australia); National Research Foundation (Denmark); Bundes Ministerium f|r Bildung und Forschung (Germany); European AIDS Treatment Network, Medical Research Council (United Kingdom); National Institute for Health Research, National Health Service (United Kingdom); and the University of Minnesota.

Publisher Copyright:
© The Author(s) 2018.

Keywords

Arterial elasticity
Cardiovascular disease
HIV infection
Systemic inflammation
Vascular dysfunction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Inflammation associates with impaired small arterial elasticity early in HIV disease",

abstract = "We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-na{\"i}ve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.",

keywords = "Arterial elasticity, Cardiovascular disease, HIV infection, Systemic inflammation, Vascular dysfunction",

author = "{INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group} and Peterson, {Tess E.} and Hullsiek, {Katherine Huppler} and Engen, {Nicole Wyman} and Nagalingeswaran Kumarasamy and Lebech, {Anne Mette} and Angelike Liappis and Antonios Papadopoulos and Polizzotto, {Mark N.} and Schreiner, {Pamela J.} and Daniel Duprez and Baker, {Jason V.}",

note = "Funding Information: Financial support. This work was supported by the National Institute of Allergy and Infectious Diseases (grant numbers UM1-AI068641, UM1-AI120197; United States); Agence Nationale de Recherches sur le SIDA et les Hipatites Virales (France); National Health and Medical Research Council (Australia); National Research Foundation (Denmark); Bundes Ministerium f|r Bildung und Forschung (Germany); European AIDS Treatment Network, Medical Research Council (United Kingdom); National Institute for Health Research, National Health Service (United Kingdom); and the University of Minnesota. Publisher Copyright: {\textcopyright} The Author(s) 2018.",

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AU - Peterson, Tess E.

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AU - Engen, Nicole Wyman

AU - Kumarasamy, Nagalingeswaran

AU - Lebech, Anne Mette

AU - Liappis, Angelike

AU - Papadopoulos, Antonios

AU - Polizzotto, Mark N.

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N2 - We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

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KW - Arterial elasticity

KW - Cardiovascular disease

KW - HIV infection

KW - Systemic inflammation

KW - Vascular dysfunction

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Inflammation associates with impaired small arterial elasticity early in HIV disease

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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