Influence of chronic ethanol consumption on the metabolism and carcinogenicity of tobacco-related nitrosamines.

G. McCoy, S. Katayama, R. Young, M. Wyatt, S. Hecht

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of chronic ethanol consumption by Syrian golden hamsters (SGH) on the carcinogenicity and target tissue metabolism of N-nitroso-pyrrolidine (NPYR) and N'-nitrosonornicotine (NNN) has been examined. Ethanol-consuming hamsters treated with NPYR developed more nasal cavity and tracheal tumours than controls. Ethanol consumption did not affect the carcino-genicity of NNN. When the metabolism of NPYR and NNN by isolated tracheal rings was examined, it was observed that tracheal rings isolated from ethanol-consuming SGH metabolized NPYR at a higher rate than similar preparations from control animals. In contrast, no differences in the rates of metabolism of NNN were observed.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalIARC scientific publications
Issue number41
StatePublished - 1982
Externally publishedYes

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