Influence of pentobarbital on synaptic plasma membrane protein synthesis

Robert J. Hitzemann; Horace H. Loh

doi:10.1016/0024-3205(77)90125-4

Influence of pentobarbital on synaptic plasma membrane protein synthesis

Robert J. Hitzemann, Horace H. Loh

Pharmacology

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2 Scopus citations

Abstract

The effects of acute and chronic pentobarbital treatment on the incorporation of ³H-lysine into rat brain synaptic plasma membranes (SPM) were examined by means of SDS polyacrylamide gel electrophoresis. The data suggest the major effects of both drug treatments are found in a unique population of SPM derived from a light population of nerve ending particles (NEP). These light NEP preferentially accumulate labelled GABA, suggesting this fraction is enriched in GABA containing nerve terminals.

Original language	English (US)
Pages (from-to)	35-41
Number of pages	7
Journal	Life Sciences
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0024-3205(77)90125-4
State	Published - Jan 1 1977

Bibliographical note

Funding Information:
Male Sprague-Dawley rats (Simonsen Laboratories, Gilroy, CA .) weighing 180-200 g were implanted with a needle guide above the lateral ventricle. Four to 7 days later, the Snimals were implanted with two placebo or two 200 mg ;This study was supported in part by USPHS Grant DA-OOS64. ent of a NINE Research Scientist Career Development Award,

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Influence of pentobarbital on synaptic plasma membrane protein synthesis

Abstract

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