Abstract
The data presented indicate that altered systolic and diastolic func-tion in failing human hearts may result from altered expression of calcium cycling proteins. Decreased systolic force production and inversion of the force-frequency relation seem to be related to reduced protein levels of SR Ca2+ ATPase and/or to increased protein levels of the Na +-Ca2+ exchanger resulting in an increased ratio of Na+- Ca2+ exchanger to SR Ca2+ ATPase. Impaired diastolic function may result from reduced SR Ca2+ ATPase and is most pronounced in failing hearts with lack of upregulation of the Na +-Ca2+ exchanger. Thus, failing hearts with reduced SR Ca2+ ATPase protein levels and unchanged Na+-Ca 2+ exchanger protein levels exhibit severe impairment of both systolic and diastolic function.
Original language | English (US) |
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Pages (from-to) | 38-45 |
Number of pages | 8 |
Journal | Basic research in cardiology |
Volume | 93 |
Issue number | 1 SUPPL. |
DOIs | |
State | Published - Oct 1998 |
Externally published | Yes |
Keywords
- Calcium channel
- Calcium pump
- Na-Ca exchanger
- Ryanodine receptor
- Sarcoplasmic reticulum