Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.
Bibliographical noteFunding Information:
We wish to thank Dr. Nobuyo Maeda (UNC-Chapel Hill, NC, USA) for helpful comments and suggestions, Ju-Ryoung Kim for FPLC analysis, Myoung-Soo Kim, Seong-Kyu Kim for their technical assistance, and Philip McElroy for the English revision. This work was financially supported by the Molecular Medicine Research Group Program (99-J03-01-01-A-05) from MOST and the SGRP/HTD Program (298045-3) from ARPC, Korea.
- Agastache rugosa
- Nuclear factor-κB
- Vascular cell adhesion molecule-1