Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

Jung Joo Hong, Jae Hoon Choi, Sei Ryang Oh, Hyeong Kyu Lee, Jae Hak Park, Kun Yeong Lee, Jung Jae Kim, Tae Sook Jeong, Goo Taeg Oh

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalFEBS Letters
Volume495
Issue number3
DOIs
StatePublished - Apr 27 2001

Bibliographical note

Funding Information:
We wish to thank Dr. Nobuyo Maeda (UNC-Chapel Hill, NC, USA) for helpful comments and suggestions, Ju-Ryoung Kim for FPLC analysis, Myoung-Soo Kim, Seong-Kyu Kim for their technical assistance, and Philip McElroy for the English revision. This work was financially supported by the Molecular Medicine Research Group Program (99-J03-01-01-A-05) from MOST and the SGRP/HTD Program (298045-3) from ARPC, Korea.

Keywords

  • Agastache rugosa
  • Atherosclerosis
  • Macrophage
  • Nuclear factor-κB
  • Tilianin
  • Vascular cell adhesion molecule-1

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