Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins

Eric P. Brass; Maureen J. Garrity; R. Paul Robertson

doi:10.1016/0014-5793(84)80336-1

Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins

Eric P. Brass, Maureen J. Garrity, R. Paul Robertson

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE₂, 15(S),15-methyl PGE₂, PGE₁ and PGE₂ all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	FEBS Letters
Volume	169
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(84)80336-1
State	Published - Apr 24 1984
Externally published	Yes

Bibliographical note

Funding Information:
This work wass upportedin part by National In-stituteso f Health grantn o. AM26177,t he Medical ResearchS ervice of the VeteransA dministration and in part by BRSG-05357a wardedb y the Biomedical Research Grant Program, Division of ResearchR esourcesN, ational Instituteso f Health. E.P.B. was the recipient of a Pharmaceutical ManufacturersA ssociation, Inc. Fellowship.

Keywords

Glucagon
Glycogenolysis
Hepatocyte
PGE
PGE analog
Prostaglandin

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title = "Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins",

abstract = "The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE2, 15(S),15-methyl PGE2, PGE1 and PGE2 all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.",

keywords = "Glucagon, Glycogenolysis, Hepatocyte, PGE, PGE analog, Prostaglandin",

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AU - Brass, Eric P.

AU - Garrity, Maureen J.

AU - Robertson, R. Paul

N1 - Funding Information: This work wass upportedin part by National In-stituteso f Health grantn o. AM26177,t he Medical ResearchS ervice of the VeteransA dministration and in part by BRSG-05357a wardedb y the Biomedical Research Grant Program, Division of ResearchR esourcesN, ational Instituteso f Health. E.P.B. was the recipient of a Pharmaceutical ManufacturersA ssociation, Inc. Fellowship.

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Y1 - 1984/4/24

N2 - The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE2, 15(S),15-methyl PGE2, PGE1 and PGE2 all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.

AB - The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE2, 15(S),15-methyl PGE2, PGE1 and PGE2 all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.

KW - Glucagon

KW - Glycogenolysis

KW - Hepatocyte

KW - PGE

KW - PGE analog

KW - Prostaglandin

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Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins

Abstract

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Keywords

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