The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE2, 15(S),15-methyl PGE2, PGE1 and PGE2 all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis.
Bibliographical noteFunding Information:
This work wass upportedin part by National In-stituteso f Health grantn o. AM26177,t he Medical ResearchS ervice of the VeteransA dministration and in part by BRSG-05357a wardedb y the Biomedical Research Grant Program, Division of ResearchR esourcesN, ational Instituteso f Health. E.P.B. was the recipient of a Pharmaceutical ManufacturersA ssociation, Inc. Fellowship.
- PGE analog