Inhibition of macrophage procoagulant activity with lipids reduces intra-abdominal abscess formation in mice

R. G. Sawyer, T. L. Pruett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Macrophage procoagulant activity (PCA) has been proposed as a critical element in the formation of intra-abdominal abscesses. We tested the ability of local and systemic lipids (a known PCA inhibitor in vitro) to alter both peritoneal macrophage PCA and mixed Escherichia coli/Bacteroides fragilis intra-abdominal abscess formation in vivo. Lipids given in- traperitoneally inhibited measured inducible peritoneal mac-rophage PCA for 8 h, and, in other animals, significantly decreased the number of abscesses formed and prevented abscesses in 29% of animals. Parallel experiments using sub-cutaneous intralipids did not show these effects. These results support the hypothesis that macrophage PCA produced locally is critical for intraperitoneal abscess formation.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalEuropean Surgical Research
Volume27
Issue number4
DOIs
StatePublished - Jan 1 1995

Keywords

  • Intra-abdominal abscess
  • Lipids
  • Macrophage procoagulant activity

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