Abstract
Macrophage procoagulant activity (PCA) has been proposed as a critical element in the formation of intra-abdominal abscesses. We tested the ability of local and systemic lipids (a known PCA inhibitor in vitro) to alter both peritoneal macrophage PCA and mixed Escherichia coli/Bacteroides fragilis intra-abdominal abscess formation in vivo. Lipids given in- traperitoneally inhibited measured inducible peritoneal mac-rophage PCA for 8 h, and, in other animals, significantly decreased the number of abscesses formed and prevented abscesses in 29% of animals. Parallel experiments using sub-cutaneous intralipids did not show these effects. These results support the hypothesis that macrophage PCA produced locally is critical for intraperitoneal abscess formation.
Original language | English (US) |
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Pages (from-to) | 222-226 |
Number of pages | 5 |
Journal | European Surgical Research |
Volume | 27 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1995 |
Keywords
- Intra-abdominal abscess
- Lipids
- Macrophage procoagulant activity