Inhibition of oncogene product enzyme activity as an approach to cancer chemoprevention. Tyrosine-specific protein kinase inhibition by daphnoretin from Thymelaea hirsuta root

Mohamed Abou-Karam, Nagwa S. El-Shaer, W. Thomas Shier

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Inhibitors of oncogene product enzyme activity were sought as a prescreen for potential cancer chemopreventive agents. Daphnoretin, a dicoumaryl ether from Thymelaea hirsuta root, inhibited the erb-b oncogene product, the tyrosine-specific protein kinase of human epidermal growth factor receptor (IC50 = 97.5 μM). Daphnoretin was moderately cytotoxic (IC50 = 21-114 μM) only in rapidly proliferating cultured mammalian cells.

Original languageEnglish (US)
Pages (from-to)282-284
Number of pages3
JournalPhytotherapy Research
Volume12
Issue number4
DOIs
StatePublished - Jun 1 1998

Keywords

  • Cultured mammalian cells
  • Cytotoxicity
  • Daphnoretin
  • Thymelaea hirsuta (L.) Endl.
  • Thymelaeaceae
  • Tyrosine kinase inhibition

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