Abstract
The exposure of mammalian cells to ultraviolet (UV) irradiation leads to the activation of transcription factors, such as AP-1 and NFκB. We demonstrate that aspirin, a promising cancer chemopreventative agent, inhibited UVC-induced AP-1 activity in JB6 cells. In JB6 cells, UVC stimulated Erks, JNKs and P38 kinase activities; aspirin only inhibited activation of JNKs, but not the other MAP kinases. Since the transcription factor AP-1 is important for the process of tumor promotion, the inhibitory effect of aspirin on AP-1 activation suggests that it can be used as a chemopreventative agent against skin cancer.
Original language | English (US) |
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Pages (from-to) | 565-568 |
Number of pages | 4 |
Journal | International Journal of Oncology |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1998 |
Keywords
- AP-1
- Aspirin
- MAP kinase
- Ultraviolet C