Inhibitor development

Jan Astermark, S. Lacroix-Desmazes, M. T. Reding

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understanding of the mechanisms involved will increase the likelihood of development of new therapeutic options for patients with hemophilia. This review summarizes genetic and non-genetic risk factors currently under evaluation, and the potential modulative effect of the von Willebrand factor on factor VIII immuno- and antigenicity. In addition, the role of T-regulatory cells in the pathogenicity of inhibitors will be discussed.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalHaemophilia
Volume14
Issue numberSUPPL. 3
DOIs
StatePublished - Jul 1 2008

Keywords

  • Factor VIII
  • Haemophilia
  • Inhibitors
  • Risk factors
  • T-regulatory cells
  • Von Willebrand factor

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