Injection of α-MSH, but not β-endorphin, into the PVN decreases POMC gene expression in the ARC

Eun Mee Kim, Martha K. Grace, Eugene O'Hare, Charles J Billington, Allen S Levine

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

β-Endorphin (β END) and α-melanocyte stimulating hormone (α-MSH), neuropeptides derived from proopiomelanocortin (POMC), have opposite effects on eating behavior. We injected rats with α-MSH (0.6 nmol) or β-END (I nmol) into the PVN (three times in a 26 h period). These doses of α-MSH and β-END decreased and increased feeding respectively. Following α-MSH administration into the PVN, mRNA levels of POMC decreased by 17%, whereas there was no significant change in gene expression of either proDynorphin or proEnkephalin. PVN injection of β-END failed to alter gene expression of POMC, proDynorphin or proEnkephalin. These data suggest that a feedback pathway exists between the PVN and ARC for α-MSH and POMC, but not for β-END and POMC.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalNeuroreport
Volume13
Issue number4
DOIs
StatePublished - Mar 25 2002

Keywords

  • ARC
  • Feeding
  • POMC
  • PVN
  • α-MSH
  • β-END

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