Insights from studying human sleep disorders

Mark W. Mahowald, Carlos H. Schenck

Research output: Contribution to journalReview articlepeer-review

198 Scopus citations


Problems with sleep are one of the commonest reasons for seeking medical attention. Knowledge gained from basic research into sleep in animals has led to marked advances in the understanding of human sleep, with important diagnostic and therapeutic implications. At the same time, research guided by human sleep disorders is leading to important basic sleep concepts. For example, sleep may not be a global, but rather a local, brain phenomenon. Furthermore, contrary to common assumptions, wakefulness, rapid eye movement (REM) and non-REM sleep are not mutually exclusive states. This striking realization explains a fascinating range of clinical phenomena.

Original languageEnglish (US)
Pages (from-to)1279-1285
Number of pages7
Issue number7063
StatePublished - Oct 27 2005

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