Insulin-like growth factor-I and cancer risk

Yasir H. Ibrahim; Douglas Yee

doi:10.1016/j.ghir.2004.01.005

Insulin-like growth factor-I and cancer risk

Yasir H. Ibrahim, Douglas Yee

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on proliferation, differentiation, and apoptosis. IGF-I has also been linked to malignant transformation. The role of the IGF-I in cancer has been recognized in both experimental and clinical settings, suggesting that the enhancement of growth factor pathways potentially could increase the risk for cancer development. In this paper, the role of IGF-I signaling in tumor regulation, and the impact of IGF-I modulation using growth hormone replacement therapy are discussed.

Original language	English (US)
Pages (from-to)	261-269
Number of pages	9
Journal	Growth Hormone and IGF Research
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.ghir.2004.01.005
State	Published - Aug 2004

Bibliographical note

Funding Information:
This work was supported by NIH Grants R01 CA74285, R01 CA89652, and PHS Cancer Center Support Grant P30 CA77398. The authors thank Bradley S. Miller for a critical review of the manuscript.

Keywords

Breast cancer
Cancer risk
Growth hormone
IGF-I

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on proliferation, differentiation, and apoptosis. IGF-I has also been linked to malignant transformation. The role of the IGF-I in cancer has been recognized in both experimental and clinical settings, suggesting that the enhancement of growth factor pathways potentially could increase the risk for cancer development. In this paper, the role of IGF-I signaling in tumor regulation, and the impact of IGF-I modulation using growth hormone replacement therapy are discussed.",

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N2 - Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on proliferation, differentiation, and apoptosis. IGF-I has also been linked to malignant transformation. The role of the IGF-I in cancer has been recognized in both experimental and clinical settings, suggesting that the enhancement of growth factor pathways potentially could increase the risk for cancer development. In this paper, the role of IGF-I signaling in tumor regulation, and the impact of IGF-I modulation using growth hormone replacement therapy are discussed.

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Insulin-like growth factor-I and cancer risk

Abstract

Bibliographical note

Keywords

UN SDGs

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