Background:Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results:Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m-2 (RR=0.56; 95% CI: 0.36-0.89).Conclusion:Coffee may protect against Type I EC in obese postmenopausal women.
Bibliographical noteFunding Information:
This study was supported by the National Institutes of Health (NIH) Grant R01 CA39742, and was approved by the IRB of the University of Minnesota.
- decaffeinated coffee
- endometrial cancer