Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

Gwen E. Dressing, Carol A. Lange

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Multiple laboratories have investigated progesterone receptor (PR) involvement in breast cancer cell cycle progression. There is now a growing body of evidence demonstrating complex interactions between PR and cell cycle regulatory proteins. Here we review the current literature linking PR to cell cycle control and discuss gaps in the current knowledge. A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers.

Original languageEnglish (US)
Pages (from-to)573-576
Number of pages4
JournalSteroids
Volume74
Issue number7
DOIs
StatePublished - Jul 2009

Keywords

  • Cell cycle
  • Cyclin D
  • Cyclin-dependent kinase 2
  • Progesterone receptor
  • p21
  • p27

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