TY - JOUR
T1 - Integrating genetic and protein–protein interaction networks maps a functional wiring diagram of a cell
AU - VanderSluis, Benjamin
AU - Costanzo, Michael
AU - Billmann, Maximilian
AU - Ward, Henry N.
AU - Myers, Chad L.
AU - Andrews, Brenda J.
AU - Boone, Charles
N1 - Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Systematic experimental approaches have led to construction of comprehensive genetic and protein–protein interaction networks for the budding yeast, Saccharomyces cerevisiae. Genetic interactions capture functional relationships between genes using phenotypic readouts, while protein–protein interactions identify physical connections between gene products. These complementary, and largely non-overlapping, networks provide a global view of the functional architecture of a cell, revealing general organizing principles, many of which appear to be evolutionarily conserved. Here, we focus on insights derived from the integration of large-scale genetic and protein–protein interaction networks, highlighting principles that apply to both unicellular and more complex systems, including human cells. Network integration reveals fundamental connections involving key functional modules of eukaryotic cells, defining a core network of cellular function, which could be elaborated to explore cell-type specificity in metazoans.
AB - Systematic experimental approaches have led to construction of comprehensive genetic and protein–protein interaction networks for the budding yeast, Saccharomyces cerevisiae. Genetic interactions capture functional relationships between genes using phenotypic readouts, while protein–protein interactions identify physical connections between gene products. These complementary, and largely non-overlapping, networks provide a global view of the functional architecture of a cell, revealing general organizing principles, many of which appear to be evolutionarily conserved. Here, we focus on insights derived from the integration of large-scale genetic and protein–protein interaction networks, highlighting principles that apply to both unicellular and more complex systems, including human cells. Network integration reveals fundamental connections involving key functional modules of eukaryotic cells, defining a core network of cellular function, which could be elaborated to explore cell-type specificity in metazoans.
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U2 - 10.1016/j.mib.2018.06.004
DO - 10.1016/j.mib.2018.06.004
M3 - Review article
C2 - 30059827
AN - SCOPUS:85050572324
SN - 1369-5274
VL - 45
SP - 170
EP - 179
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -