Integration of progesterone receptor action with rapid signaling events in breast cancer models

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Recent discoveries suggest that several protein kinases are rapidly activated in response to ligand binding to cytoplasmic steroid hormone receptors (SRs), including progesterone receptors (PRs). Thus, PRs act as ligand-activated transcription factor "sensors" for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast. Induction of rapid signaling upon progestin binding to PR-B provides a means to ensure that receptors and co-regulators are appropriately phosphorylated as part of optimal transcription complexes. Alternatively, PR-B activated kinase cascades provide additional avenues for progestin-regulated gene expression independent of PR nuclear action. Herein, an overview of progesterone/PR and signaling cross-talk in breast cancer models is provided. Kinases are emerging as key mediators of PR action. Cross-talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues, and is suspected to contribute to cancer biology.

Original languageEnglish (US)
Pages (from-to)203-212
Number of pages10
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume108
Issue number3-5
DOIs
StatePublished - Feb 2008

Keywords

  • Breast cancer
  • Cyclin D1
  • Epidermal growth factor
  • Mitogen activated protein kinase
  • Progesterone receptor
  • c-Src kinase

Fingerprint Dive into the research topics of 'Integration of progesterone receptor action with rapid signaling events in breast cancer models'. Together they form a unique fingerprint.

Cite this