Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

Katherine R. Tonn Eisinger, Kellie S. Gross, Brian P. Head, Paul G. Mermelstein

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.

Original languageEnglish (US)
Pages (from-to)130-137
Number of pages8
JournalHormones and Behavior
Volume104
DOIs
StatePublished - Aug 2018

Bibliographical note

Funding Information:
This work was supported by NIH Grants DA035008 and DA041808 (PGM). KRTE was supported by training grant DA007234 (PGM).

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • Brain
  • Drug addiction
  • Estrogen receptors
  • mGluR

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