Abstract
Many inflammatory chemical mediators excite or sensitize nociceptors, which had led some researchers to believe that they may interact with each other to maintain a persistent painful state. We examined how the excitatory mediators norepinephrine (NE) and bradykinin (BK) interact, using single fiber recordings from cutaneous nociceptors. We observed that NE augmented the BK-induced response in both control and adjuvant-inflamed rats in a way different from NE-induced excitation in inflamed animals only. BK also tended to augment the NE-induced response (examined only in inflamed rats). Our results provide the first evidence that BK and NE synergistically interact on nociceptors.
Original language | English (US) |
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Pages (from-to) | 421-425 |
Number of pages | 5 |
Journal | Neuroscience Research |
Volume | 49 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2004 |
Keywords
- Bradykinin
- Cutaneous nociceptor
- Inflammation
- Norepinephrine
- Rat