Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin response

Claus Schwechheimer, Giovanna Serino, Judy Callis, William L. Crosby, Svetlana Lyapina, Raymond J. Deshaies, William M. Gray, Mark Estelle, Xing Wang Deng

Research output: Contribution to journalArticlepeer-review

375 Scopus citations


The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-offunction mutants of the E3 ubiquitin ligase SCFTIR1. Furthermore, we found that the COP9 signalosome and SCFTIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCFTIR1. Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase-mediated responses.

Original languageEnglish (US)
Pages (from-to)1379-1382
Number of pages4
Issue number5520
StatePublished - May 18 2001


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