Abstract
The role of intercellular communication is increasingly recognized as being critical to tumoral invasion, metastasis, and development of resistance to therapy. The recent discovery of cellular protrusions – tumor microtubes – connecting cancer cells in gliomas, and tunneling nanotubes in several other forms of cancer, sheds light on a novel mechanism for molecular networking. Interrupting and disrupting vital lines of intercellular crosstalk via these membranous cellular tubes has strong potential as a novel form of cancer-directed therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-5 |
| Number of pages | 3 |
| Journal | Trends in Cancer |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
Bibliographical note
Publisher Copyright:© 2015 Elsevier Inc.
Keywords
- brain tumor networks
- cellular protrusions
- glioblastoma
- intercellular communication
- tumor microtubes
- tunneling nanotubes
