TY - JOUR
T1 - Interference in bacterial quorum sensing
T2 - A biopharmaceutical perspective
AU - Rémy, Benjamin
AU - Mion, Sonia
AU - Plener, Laure
AU - Elias, Mikael
AU - Chabrière, Eric
AU - Daudé, David
N1 - Publisher Copyright:
© 2018 Rémy, Mion, Plener, Elias, Chabrière and Daudé.
PY - 2018/3/7
Y1 - 2018/3/7
N2 - Numerous bacteria utilize molecular communication systems referred to as quorum sensing (QS) to synchronize the expression of certain genes regulating, among other aspects, the expression of virulence factors and the synthesis of biofilm. To achieve this process, bacteria use signaling molecules, known as autoinducers (AIs), as chemical messengers to share information. Naturally occurring strategies that interfere with bacterial signaling have been extensively studied in recent years, examining their potential to control bacteria. To interfere with QS, bacteria use quorum sensing inhibitors (QSIs) to block the action of AIs and quorum quenching (QQ) enzymes to degrade signaling molecules. Recent studies have shown that these strategies are promising routes to decrease bacterial pathogenicity and decrease biofilms, potentially enhancing bacterial susceptibility to antimicrobial agents including antibiotics and bacteriophages. The efficacy of QSIs and QQ enzymes has been demonstrated in various animal models and are now considered in the development of new medical devices against bacterial infections, including dressings, and catheters for enlarging the therapeutic arsenal against bacteria.
AB - Numerous bacteria utilize molecular communication systems referred to as quorum sensing (QS) to synchronize the expression of certain genes regulating, among other aspects, the expression of virulence factors and the synthesis of biofilm. To achieve this process, bacteria use signaling molecules, known as autoinducers (AIs), as chemical messengers to share information. Naturally occurring strategies that interfere with bacterial signaling have been extensively studied in recent years, examining their potential to control bacteria. To interfere with QS, bacteria use quorum sensing inhibitors (QSIs) to block the action of AIs and quorum quenching (QQ) enzymes to degrade signaling molecules. Recent studies have shown that these strategies are promising routes to decrease bacterial pathogenicity and decrease biofilms, potentially enhancing bacterial susceptibility to antimicrobial agents including antibiotics and bacteriophages. The efficacy of QSIs and QQ enzymes has been demonstrated in various animal models and are now considered in the development of new medical devices against bacterial infections, including dressings, and catheters for enlarging the therapeutic arsenal against bacteria.
KW - Antibioresistance
KW - Bacterial virulence
KW - Biofilm
KW - Medical devices
KW - Phage resistance
KW - Quorum quenching enzymes
KW - Quorum sensing (QS)
KW - Quorum sensing inhibitors
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U2 - 10.3389/fphar.2018.00203
DO - 10.3389/fphar.2018.00203
M3 - Review article
C2 - 29563876
AN - SCOPUS:85043341639
SN - 1663-9812
VL - 9
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
IS - MAR
M1 - 203
ER -