Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

Kimberly S. Schluns, William C. Kieper, Stephen C. Jameson, Leo Lefrançois

Research output: Contribution to journalArticlepeer-review

1216 Scopus citations

Abstract

The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells. We found that IL-7 was required for homeostatic expansion of naïve CD8+ and CD4+ T cells in lymphopenic hosts and for CD8+ T cell survival in normal hosts. In contrast, IL-7 was not necessary for growth of CD8+ T cells in response to a virus infection but was critical for generating T cell memory. Up-regulation of Bcl-2 in the absence of IL-7 signaling was impaired after activation in vivo. Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis.

Original languageEnglish (US)
Pages (from-to)426-432
Number of pages7
JournalNature immunology
Volume1
Issue number5
DOIs
StatePublished - Nov 2000

Bibliographical note

Funding Information:
Acknowledgments Supported by NIH grants AI35917 and DK45260 (to L. L),AI38903 and ACS RPG-99-264 (to S. C. J.), and NIH training grant AR-07582 (to K. S.) and NIH training grant AI-07313 (to W. C. K.).

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