Interspecies chimeras as a platform for exogenic organ production and transplantation

Daniel J. Garry; Mary G. Garry

doi:10.1177/15353702211024948

Interspecies chimeras as a platform for exogenic organ production and transplantation

Daniel J. Garry, Mary G. Garry

Medicine - Cardiology Division

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

Original language	English (US)
Pages (from-to)	1838-1844
Number of pages	7
Journal	Experimental Biology and Medicine
Volume	246
Issue number	16
DOIs	https://doi.org/10.1177/15353702211024948
State	Published - Aug 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the National Institutes of Health [HL144582] and the Department of Defense [grant numbers W81XWH2020047, W81XWH2020048 and W81WH1910610].

Publisher Copyright:
© 2021 by the Society for Experimental Biology and Medicine.

Keywords

Chimera
ETV2
MYF5
MYF6
MYOD
hiPSCs
somatic cell nuclear transfer

Access

10.1177/15353702211024948

OpenUrl availability

Full text

Cite this

@article{11cca7a21a31460ba6b8e6f97f0e6d28,

title = "Interspecies chimeras as a platform for exogenic organ production and transplantation",

abstract = "Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.",

keywords = "Chimera, ETV2, MYF5, MYF6, MYOD, hiPSCs, somatic cell nuclear transfer",

author = "Garry, {Daniel J.} and Garry, {Mary G.}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the National Institutes of Health [HL144582] and the Department of Defense [grant numbers W81XWH2020047, W81XWH2020048 and W81WH1910610]. Publisher Copyright: {\textcopyright} 2021 by the Society for Experimental Biology and Medicine.",

year = "2021",

month = aug,

doi = "10.1177/15353702211024948",

language = "English (US)",

volume = "246",

pages = "1838--1844",

journal = "Experimental Biology and Medicine",

issn = "1535-3702",

publisher = "Sage Publications",

number = "16",

}

TY - JOUR

T1 - Interspecies chimeras as a platform for exogenic organ production and transplantation

AU - Garry, Daniel J.

AU - Garry, Mary G.

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the National Institutes of Health [HL144582] and the Department of Defense [grant numbers W81XWH2020047, W81XWH2020048 and W81WH1910610]. Publisher Copyright: © 2021 by the Society for Experimental Biology and Medicine.

PY - 2021/8

Y1 - 2021/8

N2 - Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

AB - Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

KW - Chimera

KW - ETV2

KW - MYF5

KW - MYF6

KW - MYOD

KW - hiPSCs

KW - somatic cell nuclear transfer

UR - http://www.scopus.com/inward/record.url?scp=85108856232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85108856232&partnerID=8YFLogxK

U2 - 10.1177/15353702211024948

DO - 10.1177/15353702211024948

M3 - Review article

C2 - 34165344

AN - SCOPUS:85108856232

SN - 1535-3702

VL - 246

SP - 1838

EP - 1844

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 16

ER -

Interspecies chimeras as a platform for exogenic organ production and transplantation

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this